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Inverted immunity

Antiviral in mice, ISG15 becomes a proviral therapeutic target in humans

A cohort of interferon-stimulated gene 15 (ISG15)-deficient adolescents has revealed the protein has opposite roles in the viral immunities of mice and humans, and produced data suggesting inhibitors could provide a broad therapeutic strategy for viral pandemics.

While knocking out ISG15 makes mice more susceptible to viral infection, in humans it had the reverse effect.

“If you don’t have ISG15, you

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