Dysfunction junction

Shutting down a paracrine loop that promotes brain metastases

Researchers from Memorial Sloan Kettering Cancer Center have shown brain metastases build gap junctions to flood neighboring astrocytes with pro-inflammatory signaling molecules, causing the cells to secrete cytokines that fuel tumor growth via a paracrine feedback loop. The team has launched a pilot clinical study to see whether a gap junction inhibitor can kill the cycle and stem cancer growth in

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