ARTICLE | Tools & Techniques

Better ubiquitin screening

February 27, 2006 8:00 AM UTC

The ubiquitin proteasome pathway is involved in many cell processes, including apoptosis, immune response, cell cycle progression, gene expression regulation and DNA repair. But its complexity makes it difficult to build assays to gauge the effect of compounds in the pathway.

Cytomics Systems SA says its Ubiscreen yeast-based screening assay is more useful than non-cell-based in vitro methods because it more closely mimics the actual pathway. The company was expected to announce this week that it has raised E10 million ($11.9 million) in the first closing of a series B round led by Edmond de Rothschild Investment Partners, which will enable it to start developing compounds derived from its screens...