ARTICLE | Product Development

Prostate energy depleter

May 23, 2005 7:00 AM UTC

Men with benign prostatic hyperplasia are typically put on two drugs: Flomax to provide symptomatic relief and Proscar to shrink the prostate. A better drug would both improve symptoms and treat the underlying disease. Threshold Pharmaceuticals Inc. reported Phase II data last week indicating that its TH-070 might do just that.

Flomax tamsulosin from Boehringer Ingelheim (Ingelheim, Germany) is an antagonist of alpha (1A) adrenergic receptors in the prostate. It causes smooth muscle cells in the bladder neck and prostate to relax, thus easing urinary flow...