Chemoprotectant pathway

Protecting healthy cells from chemotherapy has long been a treatment goal, yet only one chemoprotectant is on the market - Ethyol amifostine from MedImmune Inc. Last week, Novelos Therapeutics Inc. reported data on an approach using the glutathione pathway, which protects cells by mopping up free radicals and potentially by modulating the immune system.

NVLT's NOV-002 oxidized glutathione is marketed in Russia as a chemoprotectant. Oxidized glutathione, or GSSG, is different from the more common reduced form of glutathione, or GSH. Several companies have failed to develop GSH, according to President and acting CEO Harry Palmin. NVLT is the first to develop the oxidized form...