The big Pacific

Next-generation genome sequencing play Pacific Biosciences Inc. upped the ante on its planned IPO last week. The company raised the amount to be raised to up to $230 million from the $200 million it filed for in August.

That would make it the biggest IPO this year, surpassing the $215.6 million raised by gastrointestinal company Ironwood Pharmaceuticals Inc. (NASDAQ:IRWD) in February...