ARTICLE | Product Development
Beyond statins: LDL diversity
Beyond statins: PCSK9 inhibitors slash LDL; but not for all patients
April 30, 2012 7:00 AM UTC
No fewer than 20 companies are working on next-generation lipid-lowering agents intended to improve upon the benefits of statins, which lower LDL-C and reduce the risk of cardiovascular events but still leave millions of people above target LDL-C levels. While most are developing their compounds in similar settings - generally as add-ons to high-dose statins in patients not achieving LDL-C goals - emerging data suggest different mechanisms may turn out to be appropriate for different populations.
In March two mAbs that inhibit proprotein convertase subtilisin/kexin 9 made headlines with new clinical data...