ARTICLE | Emerging Company Profile
APIM: Besting the stress defense
APIM targeting cancer cell stress defenses to treat multiple myeloma
April 23, 2012 7:00 AM UTC
Chemotherapies and other cancer drugs induce apoptosis by causing genotoxic and other cellular stresses, but the ability of cancer cells to overcome such stress can limit efficacy. By targeting a master regulator of cellular responses to stress, APIM Therapeutics A/S's lead compound could improve the efficacy of approved drugs to treat multiple myeloma and other cancers.
Proliferating cell nuclear antigen (PCNA) plays a key role in the replication of normal cells by interacting with more than 200 proteins that contain the PCNA-interacting peptide (PIP box) motif...