BioCentury
ARTICLE | Product Development

Rigosertib's arresting story

Japan's SymBio bets on dual mechanism of Onconova's rigosertib in MDS

July 18, 2011 7:00 AM UTC

Onconova Therapeutics Inc. believes the dual mechanism of its rigosertib against PLK1 and PI3K will give it an advantage over compounds that inhibit either mitosis or PI3K alone. The company also believes rigosertib will be safer than other mitotic inhibitors, including other PLK1 inhibitors in development.

Japanese in-licenser SymBio Pharmaceuticals Ltd. thinks the concept fits into its fast-moving specialty pharma model, and this month obtained rights to late-stage compound for Japan and Korea in exchange for undisclosed upfront payments, milestones and royalties...