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Coley: CpGs for immune response

Cytosine-guanine dinucleotides linked through a phosphate backbone have been shown to activate both innate and acquired immune responses. Although CpGs are rarely found in human DNA, they are common in bacterial DNA, and the human immune system recognizes CpGs as an early sign of infection and responds with a powerful immune response. Coley Pharmaceutical Group Inc. believes it can harness this action to treat various diseases, including cancer, allergy and asthma, and infectious

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