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Weighing the evidence in GPCR case

Membrane proteins have proved very difficult to crystallize, with only a single example of a G protein-coupled receptor structure in the public domain. Indeed, getting crystals is the first and most difficult step on the road to obtaining a protein's structure. Thus, the belief that 3-Dimensional Pharmaceuticals Inc. had produced the crystals of a second GPCR promised significant improvement in the ability of companies to do

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