PTC: Post-transcriptional regulation

In the central dogma of molecular biology - DNA to RNA to protein - much progress has been made in understanding (and modulating) the first step of gene expression - transcription of mRNA. But processes affecting protein translation are less well understood, even though control of RNA stability and translation may provide a number of targets for drug discovery to treat viral infections, genetic disorders, immune and inflammatory diseases and cancer. It is these processes that PTC Therapeutics Inc. is targeting.


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