Pentose: 'Nuking' viruses

As do humans, viruses rely on nucleic acids - DNA or RNA - to encode their structures and act as templates for replication. Edward Budowsky, Pentose Pharmaceuticals Inc.'s scientific founder and an expert on nucleic acid chemistry, reasoned that this fundamental role of nucleic acids in viral function made them a good target to attack with antiviral therapies.

Pentose's approach relies on the company's knowledge of nucleic acid reactivity with various classes of small molecules, especially compounds that interact with nucleic

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