Maintaining hope for Antegren

Though Antegren natalizumab from Biogen Inc. and Elan Corp. plc failed to meet the primary endpoint in a Phase III study, it is too soon to pass judgement on its utility for Crohn's disease. A high placebo response, a problem that has plagued other trials in the indication, might have masked the pharmacologic activity aimed at inducing a disease response. And it remains to be seen whether the compound will be effective as maintenance therapy.

In the ENACT-1 trial in 905 patients with moderate-to-severe disease, those taking 300

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