Ligand's march into obesity/diabetes
LGND already has one of the broadest pipelines of the mid-tier biotechs, with programs in cancer, women's health, skin and metabolic diseases, osteoporosis, cardiovascular and inflammatory disease, and seven pharmaceutical company alliances. Now, in the area of diabetes and obesity, the San Diego, Calif., company has identified five key assets: its STATs leptin signal pathway, its PPAR signal pathway, its leptin (ob) gene promoter-based pathway, and its Targretin ( LGD1069 ) compound. In addition, LGND has buy-back rights to Allergan Ligand Retinoid Therapeutics Inc. 's RXR technology, including the compound ALRT268.
STATs (signal transducers and activators of transcription) are a transcription factor superfamily. They mediate specific changes in gene expression