ARTICLE | Emerging Company Profile
Oncotide: SETting up phosphatases
Oncotide SET antagonists enhance phosphatase activity, disrupt cancer signaling
July 23, 2012 7:00 AM UTC
Oncotide Pharmaceuticals Inc. believes it has found a way to deactivate the phosphorylation that is a driver of oncogenic signaling, an approach that could provide an alternative or add-on to kinase inhibitors for blocking growth of tumor cells.
Rather than inhibiting kinases to restore normal phosphorylation and reduce the signaling of up-regulated oncogenic pathways, Oncotide is developing SET inhibitors to promote dephosphorylation of the oncogenic signaling molecules...