Axiom: Going native

Advances in combinatorial chemistry have helped drug hunters overcome the historical challenge in drug discovery: an inadequate supply of diverse compounds. But along with that progress has come the dilemma of how to screen millions of compounds efficiently to find new therapeutic candidates

Existing radio-ligand binding high throughput screening has accelerated the work, but it reveals no functional/biological information. Other technologies are attempting to screen huge numbers of molecules using genetically engineered systems, such as transfected cells, or

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