VEGF on the brain

VEGFs are best known for their ability to act on the vasculature and induce angiogenesis. But mounting preclinical evidence suggests VEGF proteins also may act as neurotrophic factors in the CNS, directly influencing the development and survival of neurons in both healthy and diseased states.^1,2

Researchers at theKatholieke Universiteit Leuvenhave now shown that VEGF-B may be used to treat amyotrophic lateral sclerosis (ALS). These findings come on the heels of an existing program by the university and partner NeuroNova ABto develop VEGF-A for the same indication. VEGF-B may turn out to be a better candidate for this degenerative disease because of fewer side effects.³...