ARTICLE | Targets & Mechanisms

Peripheral thinking in AD

How modulating Tregs could help treat AD

October 8, 2015 7:00 AM UTC

Researchers at the Weizmann Institute of Science have shown for the first time that systemic immune suppression may contribute to neuroinflammation, brain pathology and cognitive dysfunction in Alzheimer's disease (AD), and that by taking the brakes off of peripheral immunity, companies may be able to develop therapies that recruit macrophages and T cells to treat the disease.

While the results only sketch the outline of the mechanism, they point to a central role for T regulatory cells (Tregs) in the process, making the cells a target for intervention...