BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: RNA polymerase II (Pol II) polypeptide A (POLR2A); epithelial cell adhesion molecule (EpCAM)

May 7, 2015 7:00 AM UTC

Cell culture, mouse and patient sample studies suggest antibody-drug conjugates (ADCs) incorporating the Pol II inhibitor α-amanitin could help treat cancers that are hemizygous for the POLR2A gene. I...