Therapeutics: Notch 2 (NOTCH2)

In vitro and mouse studies suggest anti-NOTCH2 antibodies could help treat asthma and other diseases involving pulmonary inflammation. In a 3D culture of airway epithelial cells, an anti-NOTCH2 antibody decreased interleukin-13 (IL-13)-induced differentiation into mucus-producing globlet cells compared with a control IgG or vehicle. In an intranasal allergen challenge mouse model of allergic asthma, an anti-NOTCH2 antibody decreased lung levels of globlet cell markers and mucus compared with a control IgG. Next steps could include testing anti-NOTCH2 antibodies in additional animal models of airway diseases...