Open source database maps entire human proteome by tissue, organ and cell type.
It's taken over a decade to collect the data, but a group of Swedish researchers has developed the Human Protein Atlas, a tissue-based map of the human proteome that describes where every protein is expressed down to the level of single cells. Applications of the map range from basic and disease biology to drug design, and the hope is that it can also help predict or explain off-target toxicity.
The Swedish Human Protein Atlas (HPA) program launched the open-source database last November as an interactive map that displays the human proteome by tissue, organ or cell type. The database includes information about the expression levels of human proteins in 32 normal tissue types, various cancer tissues and human cell lines.
"The proteins that we are mapping are the building blocks of human beings and also the targets for drugs," said Mathias Uhlén, HPA program director and professor of microbiology at the