ARTICLE | Translation in Brief
Old PKIS, new probes
Looking for new leads among previously published kinase inhibitors
December 17, 2015 8:00 AM UTC
Although there are over 500 kinases in the human genome, under 100 are being actively pursued as therapeutics, because of the lack of chemical probes needed to dissect their function. A public-private partnership headed by the Structural Genomics Consortium (SGC) is finding probes for the "historically understudied kinome" by screening, annotating and sharing the published inhibitors that pharma left behind.
The Published Kinase Inhibitor Set (PKIS) project was conceived by Bill Zuercher, David Drewry and colleagues during their time at GlaxoSmithKline plc (LSE:GSK; NYSE:GSK). ...