ARTICLE | Distillery Therapeutics

Therapeutics: K-Ras (KRAS); calmodulin; protein kinase C (PKC)

December 3, 2015 8:00 AM UTC

Mouse studies suggest inhibiting the KRAS-calmodulin interaction by activating PKC could help treat KRAS-driven pancreatic cancer. In a human pancreatic cell line harboring oncogenic KRAS, the PKC activator prostratin inhibited the KRAS-calmodulin interaction and decreased tumorigenic KRAS signaling and cell viability compared with vehicle. In an orthotopic xenograft mouse model of KRAS-driven pancreatic cancer, prostratin decreased tumor growth and metastasis to the peritoneum compared with vehicle. Next steps could include testing other PKC activators in models of pancreatic cancer.

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