ARTICLE | Targets & Mechanisms

Putting a lid on cancer cell proteasomes

January 16, 2014 8:00 AM UTC

Blocking the catalytic activity of proteasomes is a tried-and-true strategy in multiple myeloma, but use of marketed inhibitors is limited by drug resistance and lack of efficacy in solid tumors. Now, a team from The Johns Hopkins University has discovered a compound that suppresses tumor growth in vitro and in animal models of multiple myeloma and ovarian cancer by blocking the regulatory subunit of proteasomes.

The molecule, RA190, could represent a new class of proteasome inhibitors for use in solid tumors and drug-resistant MM.1...