ARTICLE | Targets & Mechanisms

Positioning properdin

April 10, 2014 7:00 AM UTC

Researchers at the University of Leicester have shown that a recombinant properdin produced in collaboration with The Medicines Co. has markedly higher antibacterial activity than the native protein.1 The researchers are now working to improve the activity and homogeneity of recombinant properdin to treat a broad range of infections.

Properdin is a glycoprotein composed entirely of thrombospondin-like repeat motifs. It is typically found in circulation as a dimer, trimer or tetramer. The protein stabilizes a key enzyme called alternative pathway C3 convertase that amplifies complement system activity...