ARTICLE | Cover Story

Pre-EMP-tive strike against GBM

April 10, 2014 7:00 AM UTC

University of California, Los Angeles researchers have treated glioblastoma in mice by inhibiting epithelial membrane protein 2.1 The findings open up a new indication for spinout Paganini Biopharma Inc., which has a mAb against the target in development for triple-negative breast cancer.

Epithelial membrane protein 2 (EMP2) is expressed in multiple tissues, including heart, lung, uterus and eye, in which it interacts with integrins to regulate adhesion between cells and the extracellular matrix.2,3...