ARTICLE | Targets & Mechanisms

An obesity angle for GPR120

March 8, 2012 8:00 AM UTC

An international team of researchers has shown that dysfunction of the fatty acid receptor GPR120 leads to obesity and obesity-associated metabolic disorders such as glucose intolerance and fatty liver.1 The findings come less than two years after another team had reignited interest in GPR120 as a diabetes target.

G protein-coupled receptor 120 (O3FAR1; GPR120) was identified as a target for both diseases in late 2004 after a group in Japan reported that the receptor triggered the release of glucagon-like peptide-1 (GLP-1) ...