ARTICLE | Cover Story

The root of prostate cancer

August 26, 2010 7:00 AM UTC

A lack of useful prostate cancer models has limited research and identification of new treatments for the disease. Now, researchers at the University of California, Los Angeles have identified prostatic basal cells as the originators of prostate cancer and have developed a mouse model based on these findings, which could help identify new treatments thatattack the root of the disease and prevent recurrence.1

Although many prostate cancer models exist, the field lacks ones that can accurately replicate key aspects of the human disease, including initiation of the cancer and its progression to metastasis...