S1PR2's plaque attack

Japanese researchers have shown that inhibition of sphingosine 1-phosphate receptor 2 affects multiple cell types that contribute to atherosclerosis.¹ The question is how to develop an antagonist suitable for chronic use, given that S1PR2 is expressed on multiple cell types.

Atherosclerosis results from chronic vascular inflammation involving macrophages, epithelial cells and smooth muscle cells in blood vessels. The vascular cells'release of inflammatory cytokines, uptake of...