ARTICLE | Targets & Mechanisms

Releasing the potential of GHRH

February 11, 2010 8:00 AM UTC

Researchers at the University of Miami and the Veterans Affairs Medical Center have designed an agonist of growth hormone releasing hormone that protected rodent hearts following myocardial infarction.1 They are now seeking a partner to help move the compound into a Phase I trial to treat heart failure.

Growth hormone releasing hormone (GHRH) is a 44-amino-acid peptide produced by the hypothalamus. GHRH is approved to treat growth hormone deficiency in children and works by binding its receptor on the pituitary gland to stimulate production and release of growth hormone...