ARTICLE | Cover Story

Peripheral CNR1 antagonists to the fore

August 19, 2010 7:00 AM UTC

In the three years following an FDA panel recommendation against approval of sanofi-aventis Group's Acomplia rimonabant to treat obesity due to severe neurological side effects, centrally acting inhibitors of

cannabinoid CB1 receptor have all but disappeared from development. Now, researchers at the NIH and Northeastern University have taken the CNS out of the equation by showing that a peripheral inhibitor of the receptor treated obesity and related metabolic disorders without eliciting neurological side effects in mice even though it could not enter the CNS.1...