Growing a PEG-like alternative

Researchers at Duke University are developing a drug delivery technology that is designed to circumvent potential size limitations and manufacturing difficulties associated withpegylation.¹ The technology still needs to be tested head-to-head versus pegylation.

Pegylation involves attaching a polyethylene glycol (PEG) molecule to a protein or peptide. PEG molecules can reduce protein degradability, immunogenicity and elimination, and thus increase circulating half-life. However, controlling and tailoring pegylation reactions can be complicated and laborious for many proteins.²...