New insights into cataracts
A study by Case Western Reserve University researchers provides evidence for targeting the ephrin A2 receptor to treat age-related cortical cataracts, the most common cause of blindness.1The question is whether to modulate the receptor's activity using mAbs or small molecules or to aim downstream at oxidative stress pathways controlled by the receptor.
The mouse and human genetic study was published in PLoS Genetics by a team co-led by Bingcheng Wang, professor of pharmacology, and Sudha Iyengar, assistant professor of epidemiology and biostatistics.
Cataracts result from the accumulation of misfolded proteins in the lens. Currently, the only treatment is lens replacement surgery. Although a rare