Therapeutics: Potassium channel

Mouse studies suggest M-type potassium channel openers could improve recovery following stroke. In mouse photothrombotic and middle cerebral artery occlusion models of stroke, treatment with different M-type channel openers including Trobalt retigabine up to 6 hours after stroke decreased infarct size compared with no treatment. In the mouse models, post-stroke treatment with the M-type channel openers decreased expression of neuroinflammation markers and increased motor function and coordination compared with no treatment. Next steps could include testing the M-type channel openers in different models of stroke...