ARTICLE | Translation in Brief

Antibodies with muscle

Injection of a DNA vector encoding a dengue antibody prevented dengue infection

August 13, 2015 7:00 AM UTC

A team at Inovio Pharmaceuticals Inc. (NASDAQ:INO) has found a way to get around the inconsistent expression of DNA vectors that has hampered their use in delivering antibodies, and believes the method could be used broadly to create antibodies for infectious diseases and cancer.

According to COO Niranjan Sardesai, earlier DNA vaccine technology did not elicit consistent and robust responses when tested in the clinic. He said Inovio has improved the technology over the last few years by optimizing the DNA vectors to increase transgene expression and by increasing the efficiency of DNA delivery with improved formulations and better methods for delivery - notably, electroporation...