Chiron other research news

CHIR and collaborators published the finding that uPAR forms a stable association with integrins, the mediators of cell adhesion that contribute to inflammation, immune function, clotting and cancer. As reported in Science, a soluble form of the receptor also bound with integrins.

Urokinase is a protease primarily involved in cell invasion, metastasis and angiogenesis. The researchers reported that both uPAR-mediated adhesion and altered integrin function were blocked by a peptide that bound to uPAR and disrupted complexes of uPAR and integrins. The interaction of uPAR and integrins is a new candidate target for the design of therapeutics for conditions involving inflammation and for cancers, the report concluded. ...