ImmuLogic preclinical data

IMUL published evidence that rodents will cease seeking to self-administer cocaine when treated with a vaccine that prevents entry of cocaine into the brain by inducing antibodies to the stimulant.

As reported in Nature Medicine, rats were trained to self-administer cocaine through implanted intravenous tubes. Given mouse anti-cocaine antibodies, the rats decreased their rate of self-administration. Meanwhile, mice immunized with the vaccine and then given cocaine showed decreased drug in their brains 30 seconds after intravenous administration. Repeated dosing with cocaine did not diminish the antibody's effect. ...