Brigham and Women's Hospital other research news

Researchers reported in Science that they have identified a transcription factor, early growth response-1 (Egr-1), that stimulates the factor implicated in restenosis, platelet-derived growth factor-beta (PDGF-ß).

The gene causes endothelial cells to migrate to the injured area in a blood vessel following acute mechanical injury, such as angioplasty. Researchers noticed that Egr-1 levels increase at the injury site within 30 minutes of angioplasty in rats, and remained for two hours. Egr-1 also displaced another transcription factor, Sp1, which is found in uninjured cells. ...