Salk Institute other research news

Salk researchers and colleagues showed in Science that retroviral vectors based on lentiviruses - such as disabled HIV - can be used to stably transduce nondividing cells in vivo. In rats and cultured human macrophages, the HIV vector successfully delivered genes and showed no signs of replication. This could overcome a major limitation of currently used retroviral vectors, which can't be used for in vivo transfer in nonproliferating cells such as hepatocytes, myofibers, hematopoietic stem cells and neurons. ...