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January 3, 1995 8:00 AM UTC

The San Diego company published in Science its identification of the Ac-rfwink-NH2 peptide as the most potent synthesized from a combinatorial library of D-amino acid hexapeptides.

The compound acts at the mu receptor and induced long-lasting analgesia in mice. It appears to cross the blood-brain barrier, as its action was reversed by the antagonist naloxone administered into the brain ventricles. ...