Pupil dilation response to tropicamide data

Harvard University researchers and colleagues reported in Science that a hypersensitive response to tropicamide predicted clinical diagnosis in 14 individuals already diagnosed as having Alzheimer’s, and spotted possible disease in five people who were then found to have symptoms by cognitive testing.

One person was spotted by the eye test in the absence of any cognitive changes on psychological testing, and went on to develop signs of the disease a year later. Another person also has been identified by the eye test a year before symptoms appeared, according to a commentary in Science. ...