KIF6 test: Post-marketing study data

Researchers at Stanford University School of Medicine and colleagues reported data from an analysis of 19 case-control studies, which included 17,000 cases of non-fatal CAD and 39,369 controls mainly of European descent, showing that no increased risk of CAD was found in carriers of the 719Arg KIF6 gene polymorphism compared with non-carriers. There was also no increased risk of CAD among carriers of the polymorphism in a subset of Europeans with early-onset disease vs. similarly aged controls. The researchers said their findings do not support the clinical utility of testing for the 719Arg KIF6 gene polymorphism to identify subjects at a higher risk of developing CAD, and also question whether genotype information at the KIF6 locus can reliably identify subjects most likely to benefit from the use of statins. Data were published in the Journal of the American College of Cardiology. ...