Tranilast: Phase I data

In a placebo-controlled Phase I trial in 29 healthy volunteers, a single dose of 100-900 mg tranilast significantly reduced sUA from baseline to 24 hours by 0.24 mg/dL per 100 mg increase in dose of tranilast (p=0.0001 for all). Additionally, tranilast increased fractional excretion of uric acid over 24 hours by 1.88% per 100 mg increase in dose of tranilast (p=0.0001 for all). Data were presented at the European League Against Rheumatism meeting in Rome. ...