Afferent, Roche preclinical data

In rats, intrathecal AF-792 selectively blocked P2X3 receptors in the spinal cord and significantly inhibited micturition reflex bladder contractions as measured by cystometry vs. vehicle-treated controls (p<0.01). Data were presented at the joint meeting of the International Continence Society and the International Urogynecological Association in Toronto. ...