StemCells preclinical data

In a mouse model of chronic SCI, HuCNS-SC transplantation 30 days after an SCI that resulted in hind limb paralysis significantly improved locomotor recovery as measured by open-field locomotor testing and CatWalk gait analysis vs. vehicle-treated controls. Additionally, transplanted HuCNS-SC displayed long-term engraftment, migration, limited proliferation, and differentiation predominantly to oligodendrocytes and neurons. The company said the study is the first to show that human neural stem cells can restore mobility even when administered at time points beyond the acute phase of trauma. Data were published in PLoS ONE. ...