Roche other research news

Researchers at Roche reported that TNF receptor fusion protein can block an asthmatic reaction in rats and guinea pigs. This demonstrated for the first time that TNF is a major cause of allergic lung inflammation.

As published in The Journal of Pharmacology and Experimental Therapeutics, Ro 45-2081 blocked the enhanced airway reactivity to substance P at eight hours after antigen challenge (p<0.05). Accumulation of neutrophils and total cells in the fluid from the bronchi and alveoli also was reduced in a dose-dependent manner (p<0.05). ...