University of Minnesota other research news

University researchers published data on a novel mouse model for Alzheimer's disease, showing disabled cognition in mice bearing a human gene that over-produced beta-amyloid. The amyloid in the senile plaques associated with Alzheimer's disease is comprised of the first 42 amino acids in the larger precursor protein, APP, which ranges from 695 to 770 amino acids long.

According to the scientists, previous transgenic mice expressing both native and variant precursor genes have not demonstrated a consistent cognitive decline that corresponded to tissue changes in all relevant brain regions. The mutated mice do, the researchers said. ...