University of California other research news

University researchers have inserted a gene encoding a defective version of the HIV protease into cells susceptible to HIV infection, and have demonstrated that the gene leads to production of defective protein, as reported in The Proceedings of the National Academy of Sciences.

Normal HIV protease is composed of two identical proteins. When a defective version of the protease half, known as a trans-dominant inhibitor, was put into cells susceptible to HIV, the defective protein assembled with a normal one to form a defective dimer. ...