Alexion preclinical data

ALXN published a report on the efficacy of its MP4 protein in a mouse model of multiple sclerosis known as EAE (experimental autoimmune encephalomyelitis). MP4 is a recombinant fusion antigen of both myelin basic protein and proteolipid protein, which are components of the myelin sheath. The proteins are among those that may be attacked by a patient's immune system in the disease. MP4 is designed to induce disease-causing T cells to undergo apoptosis.

As detailed in the Journal of Clinical Investigation, twice daily injection of the agent on days 5, 7, and 9 prevented the initial and the relapsing components of EAE. After ending the shots, the mice showed no evidence of disease for more than 100 days. ...